Metastasis and circulating tumor cells

Cancer is a prominent cause of death worldwide. In most cases, it is not the primary tumor which causes death, but the metastases. Metastatic tumors are spread over the entire human body and are more difficult to remove or treat than the primary tumor. In a patient with metastatic disease, circulating tumor cells (CTCs) can be found in venous blood. These circulating tumor cells are part of the metastatic cascade. Clinical studies have shown that these cells can be used to predict treatment response and their presence is strongly associated with poor survival prospects. Enumeration and characterization of CTCs is important as this can help clinicians make more informed decisions when choosing or evaluating treatment. CTC counts are being included in an increasing number of studies and thus are becoming a bigger part of disease diagnosis and therapy management. We present an overview of the most prominent CTC enumeration and characterization methods and discuss the assumptions made \ud about the CTC phenotype. Extensive CTC characterization of for example the DNA, RNA and antigen expression may lead to more understanding of the metastatic process

The Haptic Bracelets: Gait rehabilitation after Stroke

Restoring mobility and rehabilitation of gait are high priorities for rehabilitation of neurological conditions. Cueing using metronomic rhythmic sensory stimulation has been shown to improve gait, but most versions of this approach have used auditory and visual cues. In contrast, we propose the development of a prototype wearable system for rhythmic cueing based on haptics. The main aim of this research is to investigate how real-time gait monitoring and rhythmic haptic cueing can assist with gait rehabilitation for neurological conditions

HST's hunt for intermediate-mass black holes in star clusters

Establishing or ruling out, either through solid mass measurements or upper limits, the presence of intermediate-mass black holes (IMBHs) at the centers of star clusters would profoundly impact our understanding of problems ranging from the formation and long-term dynamical evolution of stellar systems, to the nature of the seeds and the growth mechanisms of supermassive black holes. While there are sound theoretical arguments both for and against their presence in today's clusters, observational studies have so far not yielded truly conclusive IMBH detections nor upper limits. We argue that the most promising approach to solving this issue is provided by the combination of measurements of the proper motions of stars at the centers of Galactic globular clusters and dynamical models able to take full advantage of this type of data set. We present a program based on HST observations and recently developed tools for dynamical analysis designed to do just that.Comment: 7 pages; Invited talk at IAU Symposium 266 "Star clusters: basic galactic building blocks" (Rio de Janeiro, 10-14 August 2009), R. de Grijs and R.D. Lepine, eds; v2 reflects a better citation of some references and corrected typo

Modelling the Eddy Pattern in the harbour of Zeebrugge

Hydrodynamic

Closed-cycle gas flow system for cooling of high Tc d.c. SQUID magnetometers

A high Tc.d.c SQUID based magnetometer for magnetocardiography is currently under development at the University of Twente. Since such a magnetometer should be simple to use, the cooling of the system can be realized most practically by means of a cryocooler. A closed-cycle gas flow cooling system incorporating such a cooler has been designed, constructed and tested. The aimed resolution of the magnetometer is 0.1 pT Hz−1/2. The required operating temperature for the SQUIDs is 30 to about 77 K with a stability of 2 × 10−4 K Hz−1/2. After a cool-down time of 1–2 h, a stationary cooling power of at least 0.2 W is required. In the design, helium gas is cooled by a Leybold Heraeus RG 210 cryocooler, transported through a gas line, and subsequently passed through a heat exchanger on which SQUIDs can be installed. The lowest obtainable SQUID heat exchanger temperature is 31 ± 2 K. This can be reached in roughly 2–3 h with an optimal mass flow with respect to the cooling power of 6 × 10−6 kg s−1. At this mass flow the cooling power at the SQUID heat exchanger is 0.2 W at 42 K and roughly 1.2 W at 77 K. A temperature stability of 0.05 K was measured at a SQUID heat exchanger temperature of 54 K and a mass flow of 3 × 10kg s−5. The experience gained with this large cooling system will be used in the design of a smaller configuration cooling system, incorporating miniature Stirling cryocoolers. In this paper the design and the construction of the present closed-cycle system are described and test results are presented.\ud \u

Active noise compensation for multichannel magnetocardiography in an unshielded environment

A multichannel high-T/sub c/-SQUID-based heart scanner for unshielded environments is under development, Outside a magnetically shielded room, sensitive SQUID measurements are possible using gradiometers. However, it is difficult to realize large-baseline gradiometers in high-T/sub c/ materials, Therefore, the authors developed two active noise compensation techniques. In the Total Field Compensation technique, a Helmholtz type coil set is placed around the sensors. One magnetometer is used as a zero detector controlling the compensation current through the coil set. For Individual Flux Compensation, the reference signal is sent to the separate SQUIDs (or their flux transformer circuits) to compensate the local environmental noise fluxes, The latter technique was tested on low-T/sub c/ rf-SQUID magnetometers, each sensor set to a field resolution SQUID magnetometers, i.e. 0.1 pT/sub RMS///spl radic/Hz. The authors were able to suppress the environmental disturbances to such an extent that magnetocardiograms could be recorded in an ordinary environment. Here the two suppression techniques are described and experimental results are presente

Forgiveness and its associations with prosocial thinking, feeling, and doing beyond the relationship with the offender

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